Sodium Iodide

Sodium iodide is a white, crystalline salt with the chemical formula NaI

Synonyms: Sodium Monoiodide; Sodium Iodine; Sodium Iodide, Hydrous; NaI; Sodium Iodin; Sodium Iodide Dihydrate; Sodium Iodide 2 H2O; Sodium Iodide Dihydrate

Sodium Iodide USP
NaI -- 149.89 -- [CAS 7681-82-5].

Sodium Iodide contains not less than 99.0 percent and not more than 101.5 percent of NaI, calculated on the anhydrous basis.

Identification— A solution (1 in 20) responds to the tests for Sodium and for Iodide.
Alkalinity— Dissolve 1.0 g in 10 mL of water, and add 0.15 mL of 0.10 N sulfuric acid: no red color is produced by the addition of 1 drop of phenolphthalein TS.
Water: not more than 2.0%.
Iodate— It meets the requirements of the test for Iodate under Potassium Iodide, 100 mg of Sodium Iodide being used in the control.
Thiosulfate and barium— It meets the requirements of the test for Thiosulfate and barium under Potassium Iodide.
Potassium— A solution of 1.0 g in 2 mL of water yields no precipitate with 1.0 mL of sodium bitartrate TS.
Heavy metals— Dissolve 2.0 g in 25 mL of water: the limit is 0.001%.
Limit of nitrate, nitrite, and ammonia— Add 5 mL of 1 N sodium hydroxide and about 200 mg of aluminum wire to a solution of 1.0 g of Sodium Iodide in 5 mL of water, contained in a test tube of about 40-mL capacity. Insert a pledget of purified cotton in the upper portion of the test tube, and place a piece of moistened red litmus paper over the mouth of the tube. Heat in a steam bath for 15 minutes: no blue coloration of the paper is discernible.
Assay— Weigh accurately about 500 mg of Sodium Iodide, and dissolve in about 10 mL of water. Add 35 mL of hydrochloric acid, and titrate with 0.05 M potassium iodate VS until the dark brown solution which is produced becomes pale brown. Add 1 mL of amaranth TS, and continue the titration slowly until the red color just changes to yellow. Each mL of 0.05 M potassium iodate is equivalent to 14.99 mg of NaI.

Sodium Iodide BP (Ph Eur monograph 0196)

NaI -- 149.9 -- CAS 7681-82-5

DEFINITION

Content
99.0 per cent to 100.5 per cent (dried substance).

CHARACTERS
Appearance: White or almost white, crystalline powder or colourless crystals, hygroscopic.
Solubility: Very soluble in water, freely soluble in ethanol (96 per cent).

IDENTIFICATION
A. Solution S (see Tests) gives the reactions of iodides.
B. Solution S gives the reactions of sodium.

TESTS
Solution S: Dissolve 10.0 g in carbon dioxide-free water R prepared from distilled water R and dilute to 100 ml with the same solvent.
Appearance of solution: Solution S is clear (2.2.1) and colourless.
Alkalinity: To 12.5 ml of solution S add 0.1 ml of bromothymol blue solution R1. Not more than 0.7 ml of 0.01 M hydrochloric acid is required to change the colour of the indicator.
Iodates: To 10 ml of solution S add 0.25 ml of iodide-free starch solution R and 0.2 ml of dilute sulphuric acid R and allow to stand protected from light for 2 min. No blue colour develops.
Sulphates: Maximum 150 ppm.
Thiosulphates: To 10 ml of solution S add 0.1 ml of starch solution R and 0.1 ml of 0.005 M iodine. A blue colour is produced.
Iron: Maximum 20 ppm.
Dilute 5 ml of solution S to 10 ml with water R.
Heavy metals: Maximum 10 ppm.
Loss on drying: Maximum 3.0 per cent, determined on 1.00 g by drying in an oven at 105 °C for 3 h.

ASSAY
Dissolve 1.300 g in water R and dilute to 100.0 ml with the same solvent. To 20.0 ml of the solution add 40 ml of hydrochloric acid R and titrate with 0.05 M potassium iodate until the colour changes from red to yellow. Add 5 ml of chloroform R and continue the titration, shaking vigorously, until the chloroform layer is decolorised. 1 ml of 0.05 M potassium iodate is equivalent to 14.99 mg of NaI.

Sodium Iodide Analytical Reagent Grade Chemical

NaI
Formula Wt 149.89
CAS Number 7681-82-5

REQUIREMENTS
Assay: Minimum 99.5% NaI
pH of a 5% solution: 6.0-9.0 at 25C

MAXIMUM ALLOWABLE
Insoluble matter: 0.01%
Chloride and bromide (as Cl): 0.01%
Iodate (IO3): 3 ppm
Nitrogen compounds (as N): 0.002%
Phosphate (PO4): 0.001%
Sulfate (SO4): 0.005%
Barium (Ba): 0.002%
Heavy metals (as Pb): 5 ppm
Iron (Fe): 5 ppm
Calcium (Ca): 0.002%
Magnesium (Mg): 0.001%
Potassium (K): 0.01%

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