Sodium Butyrate

Formula: C4H7O2Na or CH3CH2CH2COONa
CAS Number: 156-54-7
Molar Mass: 110.08695 g
Percent Composition: C 43.640 % H 6.4090 % O 29.066 % Na 20.883 %

Appearance and properties: White or off-white and alike villus powder. Taste is slight sweet, with special cheese rancidity odor, with suction wet, alkalescence and stable for light and hot.

Introduction: Sodium butyrate is a short chain fatty acid that has effects at the molecular, cellular, and tissue level. It has long been known as an inhibitor of histone deacetylases (HDACs). In cells, this alters the expression of a select group of genes containing butyrate response elements and may also involve Sp1/Sp3 binding sites. Sodium butyrate also induces growth arrest, differentiation and apoptosis in cancer cells, primarily through its effects on HDAC activity. In addition, it suppresses inflammation, in part by reducing the expression of pro-inflammatory cytokines, including interferon-γ, interleukin (IL)-6, and, and IL-1β.

Sodium butyrate is the product that energy nutrition adjusts technology of intestinal mucosa. It is an energy source of rapid proliferation of intestinal mucosa epithelial cell, activatory lymphocyte etc., which can ensure the rapid repair of injured intestinal mucosa and accelerate proliferation and maturation. It can promote the growth of beneficial bacteria Lactobacillus, bifidobacterium and inhibit the growth of harmful bacteria Coliform in the gastrointestinal tract. In essence, reduce the diarrhea and promote the brood growth rapidly. In addition to its antineoplastic activity, sodium butyrate induces changes in cellular morphology, alters the expression of cellular genes, modulates hormone action and hormone receptors as well as growth factor receptors. Sodium butyrate has also been shown to inhibit the high fat diet-induced mammary tumorigenesis. Additionally, sodium butyrate has been used in preliminary clinical trails to treat certain acute leukemias and stable butyrate derivatives are developed with a view to use these compounds to treat mammary carcinoma.

1. Sodium butyrate has hydrophilic and lipophilic properties. It can promote the growth of beneficial bacteria and inhibit the growth of harmful bacteria in the gastrointestinal tract. Sodium butyrate is an energy source of enterocyte, which can promote growth of intestinal mucosa. Villus of intestine increase 30%

2. Sodium butyrate is an energy source of cell differentiation, which can ensure the rapid repair of injured chorion and accelerate proliferation and maturation of gastrointestinal cells.

3. Improve animal immune status.

4. Increase the absorption area of small intestine, promote the absorption of calcium, and stimulate the secretion of digestive enzymes in the gastrointestinal tract and pancreas.

5. Sodium butyrate is a good attractant which can significantly increase feed intake and regulate intestinal micro-ecological balance.

6. Sodium butyrate can improve the health and growth performance of animals and increase economic benefits for farmers. It can significantly increase feed intake and reduce PH value of gastrointestinal tract. The effect is obvious that inhibits harmful bacteria and promotes the growth of animal.

Specification:

Application: Feed additive for porket, growing pig, layer, meat chicken, fish and other animals.

Usage and Dosage
The dosage is only for guidance to starters. The best dosage is the one that suits the environment.

1. For pigs kg per ton of complete feed.
Porkets ………… 1.0-1.5
Piglets ………….. 0.5-1.0
Growing pigs …. 0.25-0.5
Finishing pigs …. 0.25-0.5
Boar …………….. 0.5-1.0

2. For poultry kg per ton of complete feed
Broilers (1-21d) ……………………………………… 0.15-0.5
Broilers (22-40d) ……………………………………. 0.10-0.30
Broilers (41- time of slaughter) Laying hens .. 0.15-0.30
Broiler breeders ……………………………………… 0.25-0.40
Broiler breeders ……………………………………… 0.3-0.6

3. Others kg per ton of complete feed
Rabbits ……………………. 1.5
Fishes ……………………… 2.0-3.0
Calves …………………….. 1.5-2.0

We also offer Encapsulate Slow Release Sodium Butyrate coated with hydrogenated vegetable oil.