Phenoxyethanol

Phenoxyethanol is the organic compound with the formula C6H5OC2H4OH. It is a colorless oily liquid. It can be classified as a glycol ether and a phenol ether. It is a common preservative in vaccine formulations. Phenoxyethanol has germicidal and germistatic properties. It is often used together with quaternary ammonium compounds. Phenoxyethanol is used as a perfume fixative; an insect repellent; an antiseptic; a solvent for cellulose acetate, dyes, inks, and resins; a preservative for pharmaceuticals, cosmetics and lubricants; an anesthetic in fish aquaculture; and in organic synthesis.

Specifications of Phenoxyethanol BP Ph Eur Grade:
C8H10O2 --- 138.2 CAS 122-99-6
Action and use: Antimicrobial preservative; also used topically in treatment of bacterial infections.

DEFINITION
2-Phenoxyethanol.
Content: 99.0 per cent m/m to 100.5 per cent m/m.

CHARACTERS
Appearance: Colourless, slightly viscous liquid.
Solubility: Slightly soluble in water, in arachis oil and in olive oil, miscible with acetone, with ethanol (96 per cent) and with glycerol.

IDENTIFICATION
First identification: C
Second identification: A, B, D
A. Refractive index: 1.537 to 1.539.
B. Ultraviolet and visible absorption spectrophotometry.
Test solution: Dissolve 80.0 mg in water and dilute to 100.0 mL with the same solvent. Dilute 10.0 mL of the solution to 100.0 mL with water.
Spectral range: 240-350 nm.
Absorption maxim: At 269 nm and 275 nm.
Specific absorbances at the absorption maxima:
- at 269 nm: 95 to 105;
- at 275 nm: 75 to 85.
C. Infrared absorption spectrophotometry.
D. Shake 2 mL with a mixture of 4 g of potassium permanganate, 5.4 g of sodium carbonate and 75 mL of water for 30 min. Add 25 g of sodium chloride and stir continuously for 60 min, filter and acidify with hydrochloric acid to about pH 1.7. The melting point of the precipitate, after recrystallisation from water is 96C to 99C.

TESTS
Relative density: 1.105 to 1.110.
Related substances: To pass the test by Gas chromatography.
Limits:
- unspecified impurities: for each impurity, maximum 0.10 per cent;
- total: maximum 0.3 per cent;
- reporting threshold: 0.05 per cent.

Specifications of Phenoxyethanol USP NF Grade:
C8H10O2 138.16
2-Phenoxyethanol;
2-Phenoxyethyl alcohol;
Ethylene glycol, 2-monophenyl ether CAS 122-99-6

DEFINITION
Phenoxyethanol contains NLT 98.0% and NMT 102.0% of phenoxyethanol (C8H10O2).

IDENTIFICATION
A. Infrared Absorption: On an undried specimen.

ASSAY
To pass the test.
Acceptance criteria: 98.0% to 102.0%

Organic Impurities: To pass the test.
Acceptance criteria: NMT 1.0%
Limit of Phenol: To pass the test.
Acceptance criteria: NMT 0.1%
Specific Gravity: 1.105 to 1.110 at 20C.

Certifications :
We manufacture Bulk Drugs / API, Excipients, Pharmaceuticals (IP/BP/USP/NF/Ph. Eur, JP/ CP), Speciality Chemicals(Pure/AR/ACS), Mineral Fortifiers, Food Chemical Codex (FCC) and Flavour chemicals. Our manufacturing facility is cGMP, GLP, ISO 9001, ISO 14001, ISO 22000, ISO/IEC 17025, FSSC 22000, FSSAI, Kosher, HALAL, EXCiPACT, WC, COPP, WHO-GMP and WC certified. We are also REACH registered for export to European countries.