Isopropyl Alcohol

Isopropyl alcohol commonly called Isopropanol is a compound with the chemical formula C3H8O. It is a colorless, flammable chemical compound with a strong odor. It is used in the manufacture of a wide variety of industrial and household chemicals, and is a common ingredient in chemicals such as antiseptics, disinfectants and detergents.

General Specifications of Isopropyl Alcohol:
Description: Clear colorless liquid with characteristic odor.
Specific gravity at 25C: 0.783 to 0.787
Refractive index at 20C: 1.376 to 1.378
Acidity maximum: 0.7 ml of 0.02 N Sodium Hydroxide required for neutralisation of 50 ml sample.
Non volatile residue w/w: 0.005%
Assay by GC: minimum 99.8%
Water content w/w: 0.1%

---

Isopropyl Alcohol USP Grade Specifications:
C3H8O -- 60.10
2-Propanol;
Isopropanol CAS 67-63-0
UNII: ND2M416302

DEFINITION
Isopropyl Alcohol contains NLT 99.0% of isopropyl alcohol (C3H8O).

IDENTIFICATION
A. Infrared Absorption
B. The retention time of the major peak of the Sample solution corresponds to the 2-propanol peak of the System suitability solution, as obtained in the Assay.

ASSAY
To pass the test by chromatography.
Acceptance criteria: NLT 99.0%

IMPURITIES
Limit of Volatile Impurities: To pass the test by chromatography.
Limit of Nonvolatile Residue: To pass the test.
Acceptance criteria: NMT 2.5 mg (0.005%)
Specific Gravity: 0.783 to 0.787
Refractive Index: 1.376 to 1.378 at 20C
Acidity:
Sample solution: To 50 mL of Isopropyl Alcohol add 100 mL of carbon dioxide-free water.
Analysis: To the Sample solution add 2 drops of phenolphthalein TS, and titrate with 0.020 N sodium hydroxide to a pink color that persists for 30 s.
Acceptance criteria: NMT 0.70 mL of 0.020 N sodium hydroxide is required for neutralization.
Water Determination: NMT 0.5%

---

Isopropyl Alcohol FCC Food Grade Specifications:
2-Propanol; Isopropanol
CH3CHOHCH3
C3H8O Formula weight 60.10
CAS 67-63-0

DESCRIPTION
Isopropyl Alcohol occurs as a clear, colorless, flammable liquid. It is miscible with water, with ethyl alcohol, with ether, and with many other organic solvents. Its refractive index at 20C is about 1.377.
Function: Extraction solvent.

REQUIREMENTS
Identification: The refractive index at 20° is about 1.377.
Assay: Not less than 99.7% of C3H8O, by weight.
Acidity: (as acetic acid) Not more than 10 mg/kg.
Distillation Range: Within a range of 1C, including 82.3C.
Lead: Not more than 1 mg/kg.
Nonvolatile Residue: Not more than 10 mg/kg.
Specific Gravity: Not more than 0.7840.
Substances Reducing Permanganate: Passes test.
Water: Not more than 0.2%.
Solubility in Water: Passes test.

---

Isopropyl Alcohol Analytical Reagent Grade
2-Propanol or Isoproponal
CH3CHOHCH3 --- Formula Weight 60.10
CAS Number 67-63-0

REQUIREMENTS
Assay: 99.5% CH3CHOHCH3

MAXIMUM ALLOWABLE
Carbonyl Compounds: 0.002% propionaldehyde and 0.002% acetone
Color (APHA):10
Residue after evaporation 0.001%
Solubility in water: Passes test
Water (H2O): 0.2%
Titrable acid or base: 0.0001 meq/g.

---

Isopropyl Alcohol BP Ph Eur Grade Specifications:
C3H8O --- 60.1 --- CAS 67-63-0

DEFINITION
Propan-2-ol.

CHARACTERS
Appearance: Clear, colourless liquid.
Solubility: Miscible with water and with ethanol (96 per cent).

IDENTIFICATION
First identification: B, C.
Second identification: A, B, D
A. Relative density: 0.785 to 0.789.
B. Refractive index: 1.376 to 1.379.
C. Infrared absorption spectrophotometry
D. To 1 mL add 4 mL of water and mix. Carefully add 2 mL of a 10 g/L solution of dimethylaminobenzaldehyde in sulfuric acid, ensuring that the liquids do not mix; a bright reddish-violet ring forms immediately at the junction of the 2 liquids. After 2-5 min, the entire sulfuric acid layer turns violet.

TESTS
Appearance: The substance to be examined is clear and colourless. Dilute 1 mL to 20 mL with water. After 5 min, the solution is clear.
Acidity or alkalinity: Gently boil 25 mL for 5 min. Add 25 mL of carbon dioxide-free water and allow to cool protected from carbon dioxide in the air. Add 0.1 mL of phenolphthalein solution. The solution is colourless. Not more than 0.6 mL of 0.01 M sodium hydroxide is required to change the colour of the indicator to pale pink.
Absorbance: Maximum 0.30 at 230 nm, 0.10 at 250 nm, 0.03 at 270 nm, 0.02 at 290 nm and 0.01 at 310 nm.
The absorbance is measured between 230 nm and 310 nm using water as the compensation liquid. The spectrum shows a steadily descending curve with no observable peaks or shoulders.
Benzene and related substances: To pass the test by Gas chromatography.
Peroxides: In a 12 mL test-tube with a ground-glass stopper and a diameter of about 15 mm, introduce 8 mL of potassium iodide and starch solution. Fill completely with the substance to be examined. Shake vigorously and allow to stand protected from light for 30 min. No colour develops.
Non-volatile substances: Maximum 20 ppm.
Water: Maximum 0.5 per cent, determined on 5.0 g.

---

Certifications :
We manufacture Bulk Drugs / API, Excipients, Pharmaceuticals (IP/BP/USP/NF/Ph. Eur, JP/ CP), Speciality Chemicals(Pure/AR/ACS), Mineral Fortifiers, Food Chemical Codex (FCC) and Flavour chemicals. Our manufacturing facility is cGMP, GLP, ISO 9001, ISO 14001, ISO 22000, ISO/IEC 17025, FSSC 22000, FSSAI, Kosher, HALAL, EXCiPACT, WC, COPP, WHO-GMP and WC certified. We are also REACH registered for export to European countries.