Isoamyl Phenyl Acetate

C13H18O2 Molecular Weight 206.28
Chemical name or synonyms: Phenyl Acetic acid Isoamyl ester,  Iso Amyl Phenyl Acetate, 3-methylbutyl 2-phenylacetate
Content Isoamyl Phenylacetate: contains not less than 98.0% of isoamyl phenylacetate (C13H18O2)
Description: Isoamyl Phenylacetate is a colorless, transparent liquid having a characteristic odor
Identification:
(1) To 2 ml of Isoamyl Phenylacetate, add 10 ml of ethanolic 10% potassium hydroxide TS, and boil gently with a reflux condenser in a water bath for 1 hour. The characteristic odor disappears, and an odor of isoamyl alcohol is evolved.
(2) To the solution of (1) above, add 10 ml of water, distill, discard 15 ml of the initial distillate, and acidify the remaining distillate with diluted hydrochloric acid. Crystals are deposited. Collect the crystals by filtration, wash with water, and recrystallize from boiling water. The melting point is 76 to 78.

1. HAZARDS IDENTIFICATION

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Skin corrosion/irritation Category 3, H315

Labeling according GHS & Regulation (EC) No 1272/2008

Signal Words: Warning

Hazard Statement:
H315: Causes skin irritation.

Precautionary Statements:
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+352: IF ON SKIN: Wash with soap and water.
P332+313: If skin irritation occurs: Get medical advice/attention.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do, continue rinsing.
P362: Take off contaminated clothing and wash before reuse.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
Xi Irritant.
Risk Phrase:
R38 = Irritating to skin.

2. COMPOSITION / INFORMATION ON INGREDIENTS

Product Name & Other Names: Iso Amyl Phenyl Acetate or Isoamyl Phenyl Acetate or Isoamyl Phenylacetate.
CAS Number: 102-19-2
EINECS EC Number: 203-012-6

4. FIRST-AID MEASURES

Always seek medical advice after the first aid treatment.

Eye Contact: Rinse immediately with plenty of water for 10 minutes at least. Contact a physician if symptoms persist.
Skin Contact: Wash thoroughly with soap and water; flush with plenty of water. Take off spoilt clothes. Contact physician if symptoms persist.
Ingestion: Wash the mouth with water; seek medical advice immediately.
Inhalation: Remove from exposure site to fresh air and keep at rest. Obtain medical advice.

5. FIRE-FIGHTING MEASURES

Extinguishing Media Recommended: CO2, foam, dry chemicals.
Non-Recommended: Do not use direct water jet on burning material.
Extinguishing Procedures: Closed containers may build up pressure at elevated temperatures. If possible, containers should be cooled with a water spray.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law. Avoid open flames or other sources of ignition.

7. HANDLING AND STORAGE

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents, strong acids, alkalis.
Fire Protection: Keep Isoamyl salicylate away from ignition sources and naked flame.

8. EXPOSURE CONTROL

Exposure Limits: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Respiratory Protection: Avoid to breath directly on the product. Apply local ventilations when appropriate.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice.

9. PHYSICAL AND CHEMICAL PROPERTIES

Appearance: Clear Colorless Mobile Liquid.
Odor: Characteristic.
Odor threshold: Not available.
pH: Not available.
Relative density: about 0.98
Melting point/freezing point: Not available.
Initial boiling point and boiling range: Not available.
Flash point: 110C.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility(ies): Not available.
Viscosity: Not available.
Molecular Formula: C13H18O2
Molecular Weight: 206.28

10. STABILITY AND REACTIVITY

Reactivity: It presents no significant reactivity hazards, by itself or in contact with water. Avoid contact with strong acids, alkali or oxidizing agents.
Decomposition: Carbon monoxide and unidentified organic compounds may be formed during combustion.

11. TOXICOLOGICAL INFORMATION

LD 50 ORAL/RAT (mg/Kg) > 5000
LD 50 DERMAL/RABBIT (mg/Kg) > 5000
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as possible or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Teratogenic Effects: Not available.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.

12. ECOLOGICAL INFORMATION

Toxicity to fish: No information available.
Persistence and Degradability: No information available.
Mobility: No information available.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.
Precautions: Prevent contamination of soil, ground and surface water.

13. DISPOSAL CONSIDERATIONS

In accordance with local environmental laws. Avoid disposing into drainage systems and into the environment.

14. TRANSPORT REGULATIONS

DOT USA, TDG Canada & ADR/RID Europe: Not Regulated.
IMDG/IMO: Not Regulated.
IATA/ICAO: Not Regulated.

15. REGULATORY INFORMATION

USA regulations:
SARA 311/312 Hazardous: See section 2.
USA California Proposition 65: Not listed.

Section 16 - Additional Information

European Labeling in Accordance with EC Directives:
H315: Causes skin irritation.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
Xi Irritant
Risk Phrase:
R38 = Irritating to skin.

Certifications :
We manufacture Bulk Drugs / API, Excipients, Pharmaceuticals (IP/BP/USP/NF/Ph. Eur, JP/ CP), Speciality Chemicals(Pure/AR/ACS), Mineral Fortifiers, Food Chemical Codex (FCC) and Flavour chemicals. Our manufacturing facility is cGMP, GLP, ISO 9001, ISO 14001, ISO 22000, ISO/IEC 17025, FSSC 22000, FSSAI, Kosher, HALAL, EXCiPACT, WC, COPP, WHO-GMP and WC certified. We are also REACH registered for export to European countries.