Isoamyl Amyl Salicylate

Amyl salicylate (pentyl ortho hydroxy benzoate or Isoamyl salicylate) is a colourless liquid related to coumarin olfactorily, frequently used to round off a composition and fix fine fragrance (floral or non-floral) even though not a constituent of volatile oils. Chances are you've smelled amyl salicylate in your favorite shampoo, deo, hair spray or fabric softener as it is so prevalent in those products or used it in your anti-rheumatism prescription.

1. PRODUCT AND COMPANY IDENTIFICATION

Product Name & Other Names: Iso Amyl Salicylate, Isoamyl Salicylate.
CAS Number: 87-20-7
EINECS EC Number: 201-730-4
FEMA Number: 2084
Molecular Formula: 2-(HO)C6H4CO2CH2CH2CH(CH3)2
Molecular Weight: 208.25
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.

2. HAZARDS IDENTIFICATION

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Skin corrosion/irritation Category 3, H315
Serious eye damage/eye irritation Category 2A, H319
Specific target organ toxicity, single exposure; Respiratory tract irritation Category 3, H335
Hazardous to the aquatic environment, long-term hazard Category 2, H411

Labeling according GHS & Regulation (EC) No 1272/2008

Signal Words: Warning

Hazard Statements:
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
H411: Toxic to aquatic life with long lasting effects.

Precautionary Statements:
P264: Wash -- thoroughly after handling.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+352: IF ON SKIN: Wash with soap and water.
P332+313: If skin irritation occurs: Get medical advice/attention.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.
P362: Take off contaminated clothing and wash before reuse.
P391: Collect spillage.
P501: Dispose of contents/container in accordance with local/national regulation.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbols:
Xi = Irritant
N = Dangerous for the environment
Risk Phrases:
R36/37/38 = Irritating to eyes, respiratory system and skin.
R51/53 = Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic.

Product Name & Other Names: Iso Amyl Salicylate, Isoamyl Salicylate.
CAS Number: 87-20-7
EINECS EC Number: 201-730-4

4. FIRST-AID MEASURES

Always seek medical advice after the first aid treatment.

Eye Contact: Rinse immediately with plenty of water for 10 minutes at least. Contact a physician if symptoms persist.
Skin Contact: Wash thoroughly with soap and water; flush with plenty of water. Take off spoilt clothes. Contact physician if symptoms persist.
Ingestion: Wash the mouth with water; seek medical advice immediately.
Inhalation: Remove from exposure site to fresh air and keep at rest. Obtain medical advice.

5. FIRE-FIGHTING MEASURES

Extinguishing Media Recommended: CO2, foam, dry chemicals.
Non-Recommended: Do not use direct water jet on burning material.
Extinguishing Procedures: Closed containers may build up pressure at elevated temperatures. If possible, containers should be cooled with a water spray.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.

Environmental precautions: Do not let the product enter drains, soil, or water sources.

Methods and materials used for containment Cleanup procedures and Storage: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law. Avoid open flames or other sources of ignition.

7. HANDLING AND STORAGE

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.

Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents, strong acids, alkalis.
Fire Protection: Keep Isoamyl salicylate away from ignition sources and naked flame.

8. EXPOSURE CONTROL

Exposure Limits: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Respiratory Protection: Avoid to breath directly on the product. Apply local ventilations when appropriate.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

9. PHYSICAL AND CHEMICAL PROPERTIES

Appearance: Iso Amyl Salicylate, Isoamyl Salicylate is colorless to pale yellow clear mobile liquid.
Odor: Sweet, Herbaceous green.
Odor threshold: Not available.
pH: Not available.
Relative density: about 1.05.
Melting point/freezing point: Not available.
Initial boiling point and boiling range: 277C.
Flash point: 110C.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility(ies): Not available.
Viscosity: Not available.
Molecular Formula: 2-(HO)C6H4CO2CH2CH2CH(CH3)2
Molecular Weight: 208.25

10. STABILITY AND REACTIVITY

Reactivity: Isoamyl salicylate presents no significant reactivity hazards, by itself or in contact with water. Avoid contact with strong acids, alkalis or oxidizing agents.
Decomposition: Carbon monoxide and unidentified organic compounds may be formed during combustion.

11. TOXICOLOGICAL INFORMATION

LD 50 ORAL/RAT (mg/Kg) 3300
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as possible or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Teratogenic Effects: Not available.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.

12. ECOLOGICAL INFORMATION

Toxicity to fish: No information available.
Persistence and Degradability: No information available.
Mobility: No information available.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.
Precautions: Prevent contamination of soil, ground and surface water.

13. DISPOSAL CONSIDERATIONS

In accordance with local environmental laws. Avoid disposing into the environment.

14. TRANSPORT REGULATIONS

DOT USA, TDG Canada & ADR/RID Europe:
UN Number: UN3082
Shipping Name: Isoamyl Salicylate.
Hazard Class: 9; Packing Group: III
IMDG/IMO & IATA/ICAO:
UN Number: UN3082
Shipping Name: Isoamyl Salicylate.
Hazard Class: 9; Packing Group: III

15. REGULATORY INFORMATION

USA:
SARA 304 Emergency release notification: Not regulated.
SARA 302 Extremely hazardous substance: Not listed.
SARA 311/312 Hazardous chemical: See section 2.
SARA 313 (TRI reporting): Not regulated.
California Proposition 65: Not Listed.

Section 16 - Additional Information

European Labeling in Accordance with EC Directives:
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
H411: Toxic to aquatic life with long lasting effects.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbols:
Xi = Irritant
N = Dangerous for the environment
Risk Phrases:
R36/37/38 = Irritating to eyes, respiratory system and skin.
R51/53 = Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic

DISCLAIMER: The information and recommendations set forth herein (hereinafter "Information") are presented in good faith and believed correct as of the date hereof. It is compiled from various sources and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules or insurance requirements applicable. This MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.

Certifications :
We manufacture Bulk Drugs / API, Excipients, Pharmaceuticals (IP/BP/USP/NF/Ph. Eur, JP/ CP), Speciality Chemicals(Pure/AR/ACS), Mineral Fortifiers, Food Chemical Codex (FCC) and Flavour chemicals. Our manufacturing facility is cGMP, GLP, ISO 9001, ISO 14001, ISO 22000, ISO/IEC 17025, FSSC 22000, FSSAI, Kosher, HALAL, EXCiPACT, WC, COPP, WHO-GMP and WC certified. We are also REACH registered for export to European countries.