Cinnamaldehyde

Cinnamaldehyde or Cinnamic Aldehyde is the organic compound that gives cinnamon its flavor and odor. This pale yellow viscous liquid occurs naturally in the bark of cinnamon trees and other species of the genus of cinnamon bark is about 90% cinnamaldehyde. The natural product is trans-cinnamaldehyde. The molecule consists of a phenyl group attached to an unsaturated aldehyde.

Uses:

The most obvious application for Cinnamic Aldehyde is as flavoring in items like chewing gum. It is also used in some perfumes of natural, sweet, or fruity scents.

As an agrichemical
Cinnamaldehyde is also used as a fungicide. Proven effective on over 40 different crops, cinnamaldehyde is typically applied to the root systems of plants. Its low toxicity and well-known properties make it ideal for agriculture. Cinnamaldehyde is an effective insecticide, and its scent is also known to repel animals like cats and dogs. Cinnamaldehyde has recently been recognized as a very effective insecticide for mosquito larvae.

As an antimicrobial
Another use for cinnamaldehyde is as an antimicrobial. Researchers from the University of Illinois at Chicago have found that cinnamic aldehyde, when used in Big Red, prevented oral bacterial growth by more than 50 percent. It is especially effective against bacteria living at the back of the tongue, reducing anaerobic bacteria populations by about 43 percent.

As an anti-cancer agent
Recent research documents anti-cancer activity of cinnamaldehyde/cinnamic aldehyde observed in cell culture and animal models of the disease.

Miscellaneous uses
Cinnamaldehyde is also known as a corrosion inhibitor for steel and other ferrous alloys in corrosive fluids.

Cinnamic Aldehyde or Cinnamaldehyde SDS SAFETY DATA SHEET
MSDS Sheet, MATERIAL SAFETY DATA SHEET 06-Dec-20

1. PRODUCT IDENTIFICATION

Product Name & Other Names: Cinnamic Aldehyde or Cinnamaldehyde or 3-PHENYL-2-PROPENAL.
CAS Number: 104-55-2
EINECS EC Number: 203-213-9
Molecular Weight: 132.16
Molecular Formula: C9H8O
Relevant uses and uses advised against (if any): Laboratory and Industrial Manufacturing.
SUPPLIER: As per letterhead.

2. HAZARDS IDENTIFICATION

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Skin corrosion/irritation Category 2, H315
Sensitization, Skin Category 1, H317
Serious eye damage/eye irritation Category 2A, H319
Specific target organ toxicity, single exposure; Respiratory tract irritation Category 3, H335
Hazardous to the aquatic environment, acute hazard Category 2, H401

Labeling according Regulation (EC) No 1272/2008

Signal Words: Warning

Hazard Statements:
H315: Causes skin irritation.
H317: May cause an allergic skin reaction.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
H401: Toxic to aquatic life.

Precautionary Statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P264: Wash … thoroughly after handling.
P272: Contaminated work clothing should not be allowed out of the workplace.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+352: IF ON SKIN: Wash with soap and water.
P332+313: If skin irritation occurs: Get medical advice/attention.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
P333+313: If skin irritation or a rash occurs: Get medical advice/attention.
P337+313: If eye irritation persists get medical advice/attention.
P362: Take off contaminated clothing and wash before reuse.
P391: Collect spillage.
P501: Dispose of contents/container in accordance with local/national regulation.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
Xi Irritant
Risk Phrases:
R36/37/38 Irritating to eyes, respiratory system, and skin.
R43 May cause sensitization by skin contact.
R51 Toxic to aquatic organisms.

3. COMPOSITION / INFORMATION ON INGREDIENTS

Product Name & Other Names: Cinnamic Aldehyde or Cinnamaldehyde or 3-PHENYL-2-PROPENAL.
CAS Number: 104-55-2
EINECS EC Number: 203-213-9
FEMA: 2286

4. FIRST-AID MEASURES

Always seek medical attention after first aid measures are provided.

Eye Contact: Rinse immediately with plenty of water for 10 minutes at least. Contact a physician if symptoms persist.
Skin Contact: Wash thoroughly with soap and water; flush with plenty of water. Take off spoilt clothes. Contact physician if symptoms persist.
Ingestion: Wash the mouth with water; seek medical advice immediately.
Inhalation: Remove from exposure site to fresh air and keep at rest. Obtain medical advice.

5. FIRE-FIGHTING MEASURES

Extinguishing Media Recommended: CO2, foam, dry chemicals.
Non-Recommended: Do not use direct water jet on burning material.
Extinguishing Procedure: Closed containers may build up pressure at elevated temperatures. If possible, containers should be cooled with a water spray.
Special Information:In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep up and remove to an approved disposal container. Avoid open flames or other sources of ignition.

7. HANDLING AND STORAGE

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong acids, alkali, or oxidizing agents.
Fire Protection: Keep away from ignition sources and naked flame.

8. EXPOSURE CONTROL

Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

9. PHYSICAL AND CHEMICAL PROPERTIES

Appearance: Clear Mobile Pale Yellow Liquid.
Odor: Strong, Sweet, Balsamic, Cinnamon bark
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Flash Point (C): 71
Boiling Point (C): 251
Melting Point (C): -8
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility(ies): Not available.
Viscosity: Not available.
Molecular Weight: 132.16
Molecular Formula: C9H8O

10. STABILITY AND REACTIVITY
Reactivity: It presents no significant reactivity hazards, by itself or in contact with water. Avoid contact with strong acids, alkali, or oxidizing agents.
Decomposition: Carbon monoxide and unidentified organic compounds may be formed during combustion.

11. TOXICOLOGICAL INFORMATION

LD 50 ORAL/RAT (mg/Kg): 2220
LD 50 DERMAL/RABBIT (mg/Kg): > 2000
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.

12. ECOLOGICAL INFORMATION

Toxicity to fish: LC50 Danio rerio (zebra fish) - 3 mg/l - 96 h
Biodegradability: Readily biodegradable.
Mobility: No information available.
Results of PBT and vPvB assessment: No data available for assessment.
Precautions: Prevent contamination of soil, ground and surface water.

13. DISPOSAL CONSIDERATIONS

In accordance with local environmental laws. Avoid disposing into drainage systems and into the environment.

14. TRANSPORT REGULATIONS

DOT USA: Not regulated as dangerous goods.
ADR/RID Europe: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods.

15. REGULATORY INFORMATION

USA:
SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313: Does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards: Acute Health Hazard, Fire Hazard
California Prop 65 Components: This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.

16 - ADDITIONAL INFORMATION

European Labeling in Accordance with EC Directives:
H315 = Causes skin irritation.
H317 = May cause an allergic skin reaction.
H319 = Causes serious eye irritation.
H335 = May cause respiratory irritation.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
Xi Irritant
Risk Phrases:
R36/37/38 Irritating to eyes, respiratory system, and skin.
R43 May cause sensitization by skin contact.
R51 Toxic to aquatic organisms.

Certifications :
We manufacture Bulk Drugs / API, Excipients, Pharmaceuticals (IP/BP/USP/NF/Ph. Eur, JP/ CP), Speciality Chemicals(Pure/AR/ACS), Mineral Fortifiers, Food Chemical Codex (FCC) and Flavour chemicals. Our manufacturing facility is cGMP, GLP, ISO 9001, ISO 14001, ISO 22000, ISO/IEC 17025, FSSC 22000, FSSAI, Kosher, HALAL, EXCiPACT, WC, COPP, WHO-GMP and WC certified. We are also REACH registered for export to European countries.