Aspartame Acesulfame

Aspartame-acesulfame salt is an artificial sweetener. It is produced by soaking a 2-1 mixture of aspartame and acesulfame potassium in an acidic solution and allowing it to crystallize; moisture and potassium are removed during this process. It is approximately 350 times as sweet as sucrose. It has been given the E number E962.  It is approved for use as an artificial sweetener in the Europe. In North America it falls under the same regulations as aspartame and acesulfame-K, and is also approved for use in China, Russia, Hong-Kong, Australia and New Zealand. It tastes like sugar, and it has no calories. It is widely used in food and pharmaceutical industry. It is white crystalline powder.

Aspartame Acesulfame USP NF Grade Specifications:
C18H23O9N3S -- 457.45
Aspartame acesulfame salt;
[2-Carboxy-β-(N-b-methoxycarbonyl-2-phenyl)ethylcarbamoyl)]ethanaminium 6-methyl-4-oxo-1,2,3-oxathiazin-3-ide-2,2-dioxide;
l-Phenylalanine, l-α-aspartyl-2-methyl ester compound with 6-methyl-1,2,3-oxathiazin-4(3H )-one 2,2-dioxide (1:1) – CAS 106372-55-8

DEFINITION
Aspartame Acesulfame contains NLT 63.0% and NMT 66.0% of aspartame, calculated on the dried basis. It contains NLT 34.0% and NMT 37.0% of acesulfame, calculated as the acid form on the dried basis.

IDENTIFICATION
A. Infrared Absorption
[Note: Do not dry specimens.]
Residue on Ignition: NMT 1.1%
Limit of Potassium: To pass the test. NMT 0.5%
Related Compounds: To pass the test. NMT 0.5%
Optical Rotation, Specific Rotation: To pass the test.
Loss on Drying: Dry a sample at 105C for 4 h: it loses NMT 0.5% of its weight.
Transmittance: The transmittance of a 1-in-100 solution of Aspartame Acesulfame in distilled water, determined in a 1-cm cell at 430 nm with a suitable spectrophotometer, is NLT 0.95.
Packaging and Storage: Preserve in well-closed containers, and store in a cool, dry place.

Aspartame-Acesulfame Salt FCC Food Grade:
APM-Ace; [2-carboxy-_-(N-(b-methoxycarbonyl-2-phenyl)ethylcarbamoyl)]ethanaminium 6-methyl-4-oxo-1,2,3-oxathiazin-3-ide-2,2-dioxide; L-Phenylalanine, L-alpha-aspartyl-2-methyl ester compound with 6-methyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide (1:1)
C18H23O9N3S Formula weight 457.45
CAS Number 106372-55-8

DESCRIPTION
Aspartame-Acesulfame Salt occurs as a white, crystalline powder. It is sparingly soluble in water and slightly soluble in alcohol.
Function: Sweetener.

REQUIREMENTS
Identification: An infrared absorption spectrum of a potassium bromide dispersion of Aspartame-Acesulfame Salt exhibits maxima only at the same wavelengths as those of a typical spectrum as shown in the section on Infrared Spectra, using the same test conditions as specified therein.
Assay: Not less than 63.0% and not more than 66.0% of aspartame, calculated on the dried basis. Not less than 34.0% and not more than 37.0% of acesulfame, calculated as acid formed on the dried basis.
5-Benzyl-3,6-dioxo-2-piperazineacetic Acid (DKP): Not more than 0.5%.
Lead: Not more than 1 mg/kg.
Loss on Drying: Not more than 0.5%.
Optical (Specific) Rotation: [alphaD20°: Between +14.5° and +16.5°, calculated on the dried basis.
Other Related Impurities: Not more than 1.0%.
Potassium: Not more than 0.5%.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

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