Antimony Potassium Tartrate

Antimony potassium tartrate, also known as potassium antimony tartrate, potassium antimontarterate, formula K2Sb2(C4H2O6)2 and is the double salt of potassium and antimony of tartaric acid. The compound has long been known as a powerful emetic. Antimony potassium tartrate hydrate is used in the treatment of schistosomiasis. It is also used in the textile industry to aid in binding certain dyes to fabrics. It finds application in medicine as an expectorant and a nauseant.

General Specifications of Antimony Potassium Tartrate:
Appearance: White crystalline powder.
Optical Rotation C = 2%, H2O: 137.0 - 145.0 deg
Assay: 99%.
Relative Density: 2.6
Solubility: Soluble in water.

Specifications of Antimony Potassium Tartrate USP Grade:
C8H4K2O12Sb2·3H2O 667.87
Antimonate(2-), bis[μ-[2,3-dihydroxybutanedioato(4-)-O1,O2:O3,O4]]-di-, dipotassium, trihydrate, stereoisomer.
Dipotassium bis[μ-[L-(+)-tartrato(4-)]]diantimonate(2-) trihydrate [28300-74-5].
Anhydrous 613.82 [11071-15-1].

Antimony Potassium Tartrate contains not less than 99.0 percent and not more than 103.0 percent of C8H4K2O12Sb2·3H2O.

Packaging and storage: Preserve in well-closed containers.
Completeness of solution meets the requirements, using a 750-mg specimen and water as the solvent.
Identification:
A: When heated to redness, it chars, emits an odor resembling that of burning sugar, and leaves a blackened residue. This residue has an alkaline reaction, and when a small fragment of it is held in a nonluminous flame, the flame is tinted violet.
B: In a solution (1 in 20), acidified with hydrochloric acid, hydrogen sulfide TS produces an orange red precipitate, which is soluble in ammonium sulfide and in 1 N sodium hydroxide.
C: It responds to the test for Tartrate.
Acidity or alkalinity: Dissolve 1.0 g in 50 mL of carbon dioxide-free water, and titrate with 0.010 N hydrochloric acid or 0.010 N sodium hydroxide to a pH of 4.5: not more than 2.0 mL is required.
Loss on drying: Dry it at 105 to constant weight: it loses not more than 2.7% of its weight.
Arsenic: Dissolve 100 mg in 5 mL of hydrochloric acid. Add 10 mL of a recently prepared solution of 20 g of stannous chloride in 30 mL of hydrochloric acid. Mix, transfer to a color comparison tube, and allow to stand for 30 minutes. Viewed downward over a white surface, the color of the solution appears no deeper than that of a blank to which has been added 15 micro-gm of arsenic (0.015%).
Lead: not more than 0.002%.
Assay: Dissolve about 500 mg of Antimony Potassium Tartrate, accurately weighed, in 50 mL of water, add 5 g of potassium sodium tartrate, 2 g of sodium borate, and 3 mL of starch, and immediately titrate with 0.1 N iodine VS to the production of a persistent blue color. Each mL of 0.1 N iodine is equivalent to 16.70 mg of C8H4K2O12Sb2·3H2O.

Specifications of Potassium Antimony Tartrate Trihydrate Reagent Grade
Antimony Potassium Tartrate Trihydrate:
K2(C4H2O6Sb)2- 3H2O --- Formula Weight 667.87
CAS Number 11071-15-1

REQUIREMENTS
Assay: 99.0-103.0% K2(C4H2O6Sb)2-3H2O

MAXIMUM ALLOWABLE
Titrable acid or base: 0.020 meq/g
Loss on drying: 2.7%
Arsenic (As): 0.015%.

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