| CAS No.: | 25704-18-1 |
| Molecular Weight: | --------- |
| Chemical Formula | CH2CH(C6H4SO3Na)-]n |
Polystyrene sulfonates are polymers derived from polystyrene by the addition of sulfonate functional groups. They are widely used as ion-exchange resins to remove ions such as potassium, calcium, and sodium from solutions in technical or medical applications.
Sodium polystyrene sulfonate is a cation-exchange resin. Sodium polystyrene sulfonate is also used to treat hyperkalemia (increased amounts of potassium in the body). Sodium polystyrene sulfonate is in a class of medications called potassium-removing agents. It works by removing excess potassium from the body.
General Specification for Sodium Polystyrene Sulfonate
Potassium Exchange Capacity (Anhydrous Basis): 110 mg/g to 135 mg/g
Sodium Content (Dried Basis): 9.4% to 11.5 %
water Determination: 10.0 %
Ammonium salts: To pass the test.
Identification: To pass the test.
Residual Solvent: To pass the test.
Sodium Polystyrene Sulfonate Suspension USP Grade
Sodium Polystyrene Sulfonate Suspension is a suspension of Sodium Polystyrene Sulfonate in an aqueous vehicle that may contain suitable suspending or stabilizing agents. It exchanges not less than 110 mg and not more than 135 mg of potassium for each g of the labeled amount of sodium polystyrene sulfonate.
Packaging and storage: Preserve in well-closed containers, protected from freezing and from excessive heat.
Microbial limits: Its total aerobic microbial count does not exceed 100 cfu per mL, its total combined molds and yeasts count does not exceed 100 cfu per mL, and it meets the requirements of the test for absence of Pseudomonas aeruginosa.
Sodium content: Not less than 9.4% and not more than 11.5%.
Potassium exchange capacity: (Anhydrous Basis) 110 mg/g to 135 mg/g.
Sodium Polystyrene Sulphonate BP Grade
Ph Eur
Action and use: Used in the treatment of hyperkalaemia.
DEFINITION
Polystyrene sulphonate resin prepared in the sodium form.
Exchange capacity: 2.8 mmol to 3.4 mmol of potassium per gram (dried substance).
Content: 9.4 per cent to 11.0 per cent of Na (dried substance).
CHARACTERS
Appearance: Almost white or light brown powder.
Solubility: Practically insoluble in water, in alcohol and in methylene chloride.
IDENTIFICATION
A. Infrared absorption spectrophotometry.
B. Suspend 0.1 g in water, add 2 ml of a 150 g/l solution of potassium carbonate, and heat to boiling. Allow to cool and filter. To the filtrate add 4 ml of potassium pyroantimonate solution and heat to boiling. Allow to cool in iced water and if necessary rub the inside of the test-tube with a glass rod. A dense white precipitate is formed.
TESTS
Styrene: To pass the test by liquid chromatography (1 ppm).
Calcium: Maximum 0.10 per cent.
Potassium: Maximum 0.10 per cent.
Heavy metals: Maximum 10 ppm.
Loss on drying: Maximum 7.0 per cent, determined on 1.000 g by drying in an oven at 105C.
Microbial contamination: Not more than 100 enterobacteria and certain other gram-negative bacteria per gram.
Sodium: To pass the test by atomic emission spectrometry
Exchange capacity: To pass the test by atomic emission spectrometry.
STORAGE
In an airtight container.
