| CAS No.: | 13292-46-1 |
| Molecular Weight: | 822.95 g/mol |
| Chemical Formula | C43H58N4O12 |
General Properties and Specifications of Rifampicin or RFP or Rifampin:
Appearance: A brick red to reddish brown crystalline powder.
Assay: 97-102%
pH: 4.5 - 6.5 for 1% aq. suspension.
IR Identification Test: Passes test.
Spectral Ratio (A334nm/A475nm): ~1.75
Suitability for Cell Culture: Passes test.
Bacterial Endotoxin Test (BET) (EU/mg = IU/mg) <0.05 EU/mg.
Melting Point: 188C.
Storage: 2C to 8C (Refrigerate). Ok to freeze. Shipping may be ambient. Light Sensitive, Moisture Sensitive, Heat Sensitive.
Rifampin USP Grade Specifications:
C43H58N4O12 --- 822.94
Rifamycin, 3-[[(4-methyl-1-piperazinyl)imino]methyl]-.
5,6,9,17,19,21-Hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[N-(4-methyl-1-piperazinyl)formimidoyl]-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11-(2H)-dione 21-acetate
CAS 13292-46-1
UNII: VJT6J7R4TR
Rifampin contains not less than 95.0 percent and not more than 103.0 percent of C43H58N4O12, calculated on the dried basis.
Identification: Infrared Absorption.
Crystallinity: meets the requirements.
pH: between 4.5 and 6.5, in a suspension (1 in 100).
Loss on drying: Dry about 100 mg in a capillary-stoppered bottle in vacuum at 60C for 4 hours: it loses not more than 2.0% of its weight.
Related substances: Passes the test.
Rifampicin BP Ph Eur Grade Specifications:
C43H58N4O12 --- 823 CAS 13292-46-1
DEFINITION
(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-Pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[[(4-methylpiperazin-1-yl)imino]methyl]-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienimino)naphto[2,1-b]furan-21-yl acetate.
Semi-synthetic antibiotic obtained from rifamycin SV.
Content: 97.0 per cent to 102.0 per cent (dried substance).
CHARACTERS
Appearance: Reddish-brown or brownish-red, crystalline powder.
Solubility: Slightly soluble in water, soluble in methanol, slightly soluble in acetone and in ethanol (96 per cent).
IDENTIFICATION
A. Ultraviolet and visible absorption spectrophotometry.
B. Infrared absorption spectrophotometry.
C. Suspend about 25 mg in 25 mL of water, shake for 5 min and filter. To 5 mL of the filtrate add 1 mL of a 100 g/L solution of ammonium persulfate in phosphate buffer solution pH 7.4 and shake for a few minutes. The colour changes from orange-yellow to violet-red and no precipitate is formed.
For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.
We also manufacture and supply as under:
Rifampicin or RFP or Rifampin.
Manufacturers:
MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +912223770100, +912223726950
Current Date Time in India GMT+5:30
e-mail: info@mubychem.com
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