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Sodium stibogluconate, sold under the brand name Pentostam among others and it is used in pharmacy.
Sodium Stibogluconate BP Grade
Sodium Stibogluconate is mainly the disodium salt of μ-oxy-bis[gluconato(3-)-c2,c3,c4hydroxoantimony]. It contains not less than 30.0% and not more than 34.0% of antimony(V), calculated with reference to the dried and methanol-free substance.
The method of manufacture is such as to ensure consistently controlled reaction stoichiometry in order to yield sodium stibogluconate that is satisfactory with regard to intrinsic toxicity.
A colourless, mostly amorphous powder.
Very soluble in water; practically insoluble in ethanol (96%) and in ether.
A. A solution is dextrorotatory.
B. Pass hydrogen sulphide into a 5% w/v solution for several minutes. An orange precipitate is produced.
C. When heated, it chars without melting leaving a residue which yields the reactions characteristic of antimony compounds and the reactions characteristic of sodium salts.
Stability and acidity of solution: Heat a solution containing the equivalent of 10% w/v of antimony(V) in an autoclave at 115.5C and at a pressure of 70 kPa for 30 minutes. The resulting solution is colourless or almost colourless and has a pH of 5.0 to 5.6.
Antimony(III): Dissolve 2 g in 30 ml of water, add 15 ml of hydrochloric acid and titrate with 0.00833M potassium bromate using methyl orange solution as indicator. Not more than 1.3 ml of 0.00833M potassium bromate is required.
Chloride: Dissolve 2.5 g in 50 ml of water and add 2 ml of 2M nitric acid and 75 ml of acetate buffer pH 5.0 . Titrate with 0.1M silver nitrate determining the end point potentiometrically. Not more than 3.0 ml of 0.1M silver nitrate is required.
Methanol: Not more than 2.0% w/w when determined by the method.
Loss on drying: When dried to constant weight at 130C at a pressure not exceeding 0.7 kPa, loses not more than 15.0% of its weight. Use 1 g.
ASSAY: Dissolve 0.16 g in 30 ml of hydrochloric acid , add 70 ml of orthophosphoric acid and stir carefully until completely mixed. Titrate with 0.05M ammonium iron( II ) sulphate prepared using sulphuric acid (1%) and determining the end point potentiometrically using a platinum electrode and a silver-silver chloride reference electrode. Each ml of 0.05M ammonium iron(II) sulphate is equivalent to 3.044 mg of antimony(V).
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