Nebivolol Hydrochloride

Nebivolol is used to treat high blood pressure (hypertension). Nebivolol is a beta-blocker.

General Properties and Specifications of Nebivolol Hydrochloride or Narbivolol, or Nebilet:
Appearance: White to off-white powder.
Assay: Between 98% and 102%
Identifications: By comparison with standard. IR and HPLC.
Solubility: Soluble in water. Sparingly soluble in Dimethylformamide and slightly soluble in Methanol.
Related substance impurity: Single impurity >0.5% and total impurity >1%
Heavy metals: >20 ppm.
Sulfated ash: >0.2%

Residual solvent:
Methanol: >3000 ppm.
Acetonitrile: >410 ppm.
Isopropyl alcohol: >5000 ppm.
Diisopropyl ether: >1000 ppm.
Water by KF: >1%
Melting point: 219C to 222C.
Storage: 2C to 8C Refrigerate. OK to freeze. Shipping may be at room temperature. Protect from light.