Metoprolol Succinate is a beta-blocker used to treat chest pain, heart failure, and high blood pressure. Metoprolol Succinate. Metoprolol Succinate is a long-acting beta blocker that works specifically on the heart. It works by slowing down the heart rate and makes the heart more efficient at pumping blood around the body. Metoprolol succinate is a white crystalline powder with a molecular weight of 652.8. It is freely soluble in water; soluble in methanol; sparingly soluble in ethanol.

General Properties and Specifications of Metoprolol Succinate:
Appearance: White or almost white, crystalline powder.
Assay: 985 minimum.
Melting Point: 142C to 148C.
Boiling Point: 399C.
Solubility: It is freely soluble in water; soluble in methanol; sparingly soluble in ethanol.
Storage: Store at 4C in tightly closed containers, protected from light.

Metoprolol Succinate USP Grade Specifications:
(C15H25NO3)2-C4H6O4 --- 652.82
2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (±)-, butanedioate (2:1) (salt).
(±)-1-(Isopropylamino)-3-[p-(2-methoxyethyl)phenoxy]-2-propanol succinate (2:1) (salt) CAS 98418-47-4.
UNII: TH25PD4CCB
UNII: GEB06NHM23

Metoprolol Succinate contains not less than 98.0 percent and not more than 102.0 percent of (C15H25NO3)2-C4H6O4, calculated on the dried basis.

Metoprolol Succinate BP Ph Eur Grade:
C34H56N2O10 --- 653 CAS 98418-47-4

Metoprolol Succinate USP Grade Specifications:
(C15H25NO3)2-C4H6O4 --- 652.82
2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (±)-, butanedioate (2:1) (salt).
(±)-1-(Isopropylamino)-3-[p-(2-methoxyethyl)phenoxy]-2-propanol succinate (2:1) (salt) CAS 98418-47-4.
UNII: TH25PD4CCB
UNII: GEB06NHM23

Metoprolol Succinate contains not less than 98.0 percent and not more than 102.0 percent of (C15H25NO3)2-C4H6O4, calculated on the dried basis.

Clarity and color of solution: A solution of Metoprolol Succinate having a concentration of 20 mg per mL is not less clear than an equal volume of water in a test tube of similar size. The absorbance of the solution determined at 440 nm in a 5-cm cell, using water as the blank, is not more than 0.1.
Identification: Infrared Absorption.
pH: between 7.0 and 7.6, in a solution containing 65 mg per mL.
Loss on drying: Dry it in vacuum at 60C for 4 hours: it loses not more than 0.2% of its weight.
Residue on ignition: not more than 0.1%.
Related compounds: To pass the test.

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Metoprolol Succinate BP Ph Eur Grade:
C34H56N2O10 --- 653 CAS 98418-47-4

DEFINITION
Bis[(2RS)-1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]propan-2-ol] butanedioate.
Content: 99.0 per cent to 101.0 per cent (dried substance).

CHARACTERS
Appearance: White or almost white, crystalline powder.
Solubility: Freely soluble in water, soluble in methanol, slightly soluble in ethanol (96 per cent), very slightly soluble in ethyl acetate.

IDENTIFICATION
Infrared absorption spectrophotometry.

TESTS
Solution S: Dissolve 0.500 g in carbon dioxide-free water and dilute to 25.0 mL with the same solvent.
Appearance of solution: Solution S is not more opalescent than reference suspension II and is colourless.
pH: 7.0 to 7.6 for solution S.
Impurities ;M, N, O: to pass the test by Thin-layer chromatography.
Related substances: To pass the test by Liquid chromatography.

For Original Monographs of IP Indian Pharmacopoeia EP Ph Eur European Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

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